Regulatory ncRNA processing

Across TCGA patient cohorts, RNA activity of the Regulatory ncRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPB41L4A_S543, DDAH2, and FGF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulatory ncRNA processing activity versus EPB41L4A_S543 in OV (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EPB41L4A_S543 →	-0.524	-0.024	.003	.003	3	5
COAD	DDAH2 →	+0.335	+0.019	.005	.001	3	4
COAD	FGF2 →	+0.560	+0.021	<.001	.001	3	4
HNSC	PHLDB1_S419 →	+0.604	+0.083	<.001	.009	3	4
OV	KHDRBS1_S58 →	+0.591	+0.023	.007	.007	2	5
LSCC	WDR70 →	+0.401	+0.039	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070918 vs EPB41L4A_S543 — OV

Explore this scatter interactively →