Regulation of bile acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of bile acid biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP7A1, NR1H4, and CES1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP7A1 grouped by Regulation of bile acid biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CYP7A1 →	-0.444	-1.422	.004	<.001	3	8
BREAST	NR1H4 →	-0.291	-1.041	<.001	<.001	3	7
OVARY	CES1 →	-0.201	-1.085	.006	.003	3	6
BREAST	NR1D1 →	-0.282	-1.031	.001	<.001	3	6
CNS	GNB1 →	+0.152	+0.950	.009	.003	3	6
PANCREAS	STAR →	-0.161	-1.212	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP7A1 by Regulation of bile acid biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →