Regulation of bile acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of bile acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIRREL1, XBP1, and SRPX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIRREL1 grouped by Regulation of bile acid biosynthetic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	KIRREL1 →	-2.115	-1.456	<.001	<.001	3	6
BREAST	XBP1 →	+1.583	+0.849	.005	.005	3	5
LIVER	SRPX →	-2.593	-1.623	.004	<.001	3	5
BREAST	MCF2L →	+2.310	+1.185	<.001	<.001	3	5
LIVER	GNG10 →	-1.075	-1.531	<.001	<.001	3	5
CNS	MMP2 →	-2.862	-0.890	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIRREL1 by Regulation of bile acid biosynthetic process activity — BONE

Explore this box plot interactively →