Regulation of bile acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of bile acid biosynthetic process pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Vinblastine, Cytarabine, and Palbociclib, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Vinblastine grouped by Regulation of bile acid biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Vinblastine →	-1.693	-0.419	.016	.027	3	1
LUNG_SCLC	Cytarabine →	-1.496	-0.419	.025	.027	3	1
LUNG_SCLC	Palbociclib →	-0.877	-0.364	.026	.011	3	1
LUNG_SCLC	Piperlongumine →	-0.539	-1.798	.015	<.001	3	1
LUNG_SCLC	LFM-A13 →	+0.498	+1.164	.032	.022	3	1
LUNG_SCLC	BPD-00008900 →	-0.509	-0.419	.028	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Vinblastine by Regulation of bile acid biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →