Response to interleukin-15

Across TCGA cell cohorts, RNA activity of the Response to interleukin-15 pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT3, TMEM221, and CSF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-15 activity versus STAT3 in BLOOD_Lymphoma (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	STAT3 →	+1.594	+0.211	<.001	<.001	3	6
OVARY	TMEM221 →	-0.628	-0.091	<.001	.003	3	6
SOFT_TISSUE	CSF1 →	+2.202	+0.141	<.001	.004	3	6
BLOOD_Leukemia	RIMBP3B →	-0.261	-0.111	<.001	<.001	3	6
BLOOD_Leukemia	PCBP4 →	-1.022	-0.103	<.001	<.001	3	6
BLOOD_Lymphoma	RBM4B →	-0.988	-0.267	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070672 vs STAT3 — BLOOD_Lymphoma

Explore this scatter interactively →