Response to interleukin-12

Across TCGA cell cohorts, RNA activity of the Response to interleukin-12 pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C12orf60, RPL3, and FARSA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C12orf60 grouped by Response to interleukin-12-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C12orf60 →	-0.802	-1.004	.001	.002	3	6
BREAST	RPL3 →	+0.507	+0.947	.004	<.001	3	3
OVARY	FARSA →	-0.601	-1.372	.001	<.001	3	3
OVARY	FAM53B →	-0.638	-1.118	.005	.006	3	3
LUNG_NSCLC_LUSC	NKAP →	-0.794	-1.830	<.001	<.001	3	3
LUNG_NSCLC_LUSC	EARS2 →	-0.815	-1.357	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C12orf60 by Response to interleukin-12 activity — CNS

Explore this box plot interactively →