Transepithelial transport

Across TCGA patient cohorts, RNA activity of the Transepithelial transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1247, RIF1_S782, and SETDB1_S1066, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transepithelial transport activity versus TOP2A_S1247 in LUAD (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A_S1247 →	-1.049	-0.054	<.001	<.001	3	9
GBM	RIF1_S782 →	-0.589	-0.056	<.001	<.001	3	8
UCEC	SETDB1_S1066 →	-1.107	-0.101	<.001	<.001	3	8
UCEC	UBE2T →	-0.455	-0.056	.002	.007	3	8
UCEC	CDCA8_S219 →	-0.777	-0.070	<.001	<.001	3	8
COAD	TSR1 →	-0.265	-0.035	<.001	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070633 vs TOP2A_S1247 — LUAD

Explore this scatter interactively →