Regulation of centromeric sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Regulation of centromeric sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN14P12, MAN1A1, and RNASE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of centromeric sister chromatid cohesion activity versus SEPTIN14P12 in LSCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEPTIN14P12 →	+0.704	+0.217	<.001	<.001	3	5
GBM	MAN1A1 →	-1.057	-0.534	<.001	.001	3	5
LUAD	RNASE1 →	-1.136	-0.168	.004	.006	3	4
LSCC	FLI1 →	-0.531	-0.186	<.001	.001	3	4
HNSC	LRRK2 →	-0.519	-0.197	.001	.007	3	4
BRCA	MIR3189 →	-1.676	-0.234	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070602 vs SEPTIN14P12 — LSCC

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