Centromeric sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Centromeric sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDEL1, PLP2, and TULP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDEL1 grouped by Centromeric sister chromatid cohesion-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NDEL1 →	+0.780	+0.231	<.001	.002	3	5
BLOOD_Myeloma	PLP2 →	+1.729	+0.260	.008	.006	3	4
BREAST	TULP1 →	+0.228	+0.068	.004	.009	3	4
BLOOD_Leukemia	AHNAK →	+2.334	+0.113	.001	<.001	3	4
BREAST	SLC35B2 →	+0.515	+0.113	.003	<.001	3	4
LIVER	STEAP1B →	+3.283	+0.260	<.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDEL1 by Centromeric sister chromatid cohesion activity — BLOOD_Lymphoma

Explore this box plot interactively →