Response to fatty acid

Across TCGA cell cohorts, RNA activity of the Response to fatty acid pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAX1BP3, CNTROB, and DKK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fatty acid activity versus TAX1BP3 in SOFT_TISSUE (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TAX1BP3 →	-1.550	-1.547	.004	.001	3	6
OESOPHAGUS	CNTROB →	-0.606	-1.182	.009	<.001	3	5
OVARY	DKK1 →	-3.852	-1.030	.002	.005	2	6
OVARY	FRMD6 →	-2.310	-1.087	.001	.002	3	5
STOMACH	THBS1 →	-4.375	-1.280	.004	.003	3	5
OESOPHAGUS	STK10 →	-1.215	-0.973	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070542 vs TAX1BP3 — SOFT_TISSUE

Explore this scatter interactively →