Calcium ion import

Across TCGA cell cohorts, RNA activity of the Calcium ion import pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D3H, ZNF669, and RANBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D3H grouped by Calcium ion import-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TBC1D3H →	+0.083	+2.160	.009	<.001	2	5
STOMACH	ZNF669 →	+0.229	+1.964	.003	<.001	3	3
STOMACH	RANBP1 →	+0.259	+1.868	.005	<.001	3	3
SKIN	ALAS2 →	+0.114	+0.989	.008	.004	3	3
LARGE_INTESTINE	KNDC1 →	-0.124	-0.876	.008	.008	3	3
UPPER_AERODIGESTIVE_TRACT	PCDHGB1 →	-0.120	-1.962	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D3H by Calcium ion import activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →