Regulation of microtubule cytoskeleton organization

Across TCGA patient cohorts, RNA activity of the Regulation of microtubule cytoskeleton organization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANLN, MAP1B_S1965, and SMC4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule cytoskeleton organization activity versus ANLN in LUAD (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ANLN →	+0.624	+0.034	<.001	<.001	3	8
LSCC	MAP1B_S1965 →	+0.868	+0.028	<.001	<.001	3	7
LSCC	SMC4 →	+0.486	+0.042	<.001	<.001	3	7
LUAD	MCM2 →	+0.573	+0.039	<.001	<.001	3	7
LSCC	RFC2 →	+0.358	+0.046	.003	<.001	3	7
LUAD	MCM7 →	+0.559	+0.039	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070507 vs ANLN — LUAD

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