Leukocyte aggregation

Across TCGA cell cohorts, RNA activity of the Leukocyte aggregation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBB4A, UNK, and FAM53A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUBB4A grouped by Leukocyte aggregation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TUBB4A →	-2.993	-1.672	<.001	<.001	3	4
SOFT_TISSUE	UNK →	+1.245	+1.416	.006	<.001	3	4
LUNG_NSCLC_LUAD	FAM53A →	-0.747	-0.714	<.001	.004	3	4
SOFT_TISSUE	HDAC9 →	+1.697	+1.041	<.001	.001	3	4
STOMACH	CES2 →	-2.077	-0.988	.001	.001	3	4
CNS	FAM243B →	+0.302	+0.714	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUBB4A by Leukocyte aggregation activity — SOFT_TISSUE

Explore this box plot interactively →