Leukocyte aggregation

Across TCGA pan-cancer cohorts, RNA activity of the Leukocyte aggregation pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 13 member genes.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher Leukocyte aggregation pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and CHOL, show the opposite pattern, with higher activity associated with better survival.

ESCA, GBM, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	III,IV	0.718	0.423	.002	41	view →
GBM	OS	Quartile	All	0.281	0.461	.005	30	view →
LUAD	DFS	Median	IV	0.507	0.868	.003	25	view →
COAD	OS	Median	All	0.804	0.915	.010	22	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	21	view →
LGG	OS	Tertile	All	0.708	0.903	.002	20	view →
KIRP	DFS	Median	II,III,IV	0.327	0.750	.018	20	view →
LAML	DFS	Tertile	All	0.252	0.540	.037	16	view →
THCA	DFS	Tertile	III,IV	0.868	0.970	.016	15	view →
READ	DFS	Median	III,IV	0.719	0.364	.003	14	view →
UCS	OS	Tertile	IV	1.000	0.303	.033	12	view →
MESO	OS	Median	All	0.304	0.665	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0070486–ESCA (OS)

Open the ESCA breakdown →