Actin polymerization-dependent cell motility

Across TCGA patient cohorts, RNA activity of the Actin polymerization-dependent cell motility pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENAH, C1orf105, and RBM11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin polymerization-dependent cell motility activity versus ENAH in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ENAH →	+0.735	+0.172	.002	<.001	3	5
UCEC	C1orf105 →	+0.443	+0.143	.001	<.001	3	4
CCRCC	RBM11 →	+0.393	+0.221	.001	.008	3	4
HNSC	FASLG →	-0.809	-0.084	<.001	.004	3	3
HNSC	MYO1G →	-0.801	-0.120	<.001	.004	3	3
UCEC	SLC30A3 →	+0.316	+0.156	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070358 vs ENAH — BRCA

Explore this scatter interactively →