Actin polymerization-dependent cell motility

Across TCGA pan-cancer cohorts, RNA activity of the Actin polymerization-dependent cell motility pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Actin polymerization-dependent cell motility pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and UCS, show the opposite pattern, with higher activity associated with better survival.

MESO, LUAD, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.409	0.685	.003	69	view →
LUAD	DFS	Tertile	All	0.743	0.608	.002	58	view →
THCA	DFS	Tertile	II,III,IV	0.574	0.927	.002	41	view →
KIRC	DFS	Tertile	IV	0.353	0.639	.002	30	view →
UVM	DFS	Median	III,IV	0.325	0.713	.003	23	view →
UCS	DFS	Median	IV	0.909	0.416	.008	18	view →
PRAD	DFS	Median	All	0.962	0.905	.005	18	view →
KICH	DFS	Quartile	III,IV	0.284	0.912	.004	16	view →
READ	OS	Quartile	All	0.659	1.000	.019	15	view →
TGCT	DFS	Tertile	All	0.481	0.798	.005	12	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	10	view →
LGG	OS	Quartile	All	0.299	0.730	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0070358–MESO (OS)

Open the MESO breakdown →