Actin polymerization-dependent cell motility

Across TCGA cell cohorts, RNA activity of the Actin polymerization-dependent cell motility pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA0319, MRNIP, and ZNF789, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIAA0319 grouped by Actin polymerization-dependent cell motility-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KIAA0319 →	-1.316	-1.346	<.001	<.001	3	4
LUNG_SCLC	MRNIP →	-0.998	-1.697	.001	<.001	3	4
SOFT_TISSUE	ZNF789 →	-0.724	-0.893	.001	.008	3	4
LUNG_SCLC	SAMD15 →	-1.028	-1.302	.006	.003	3	3
BLOOD_Myeloma	METRNL →	+2.244	+0.456	.003	.001	3	3
LUNG_SCLC	CCDC40 →	-1.896	-1.559	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIAA0319 by Actin polymerization-dependent cell motility activity — LUNG_SCLC

Explore this box plot interactively →