Actin polymerization-dependent cell motility

Across TCGA cell cohorts, RNA activity of the Actin polymerization-dependent cell motility pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ICAM3, DBI, and YPEL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin polymerization-dependent cell motility activity versus ICAM3 in CNS (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ICAM3 →	+0.750	+0.257	<.001	.001	3	5
BLOOD_Lymphoma	DBI →	+1.558	+0.223	<.001	.004	3	5
BLOOD_Leukemia	YPEL1 →	-1.502	-0.187	.001	.001	3	5
BLOOD_Leukemia	CRKL →	-0.660	-0.203	.002	<.001	3	4
BLOOD_Leukemia	DEPDC1B →	-0.603	-0.182	.008	<.001	3	4
SKIN	DPYSL2 →	+1.277	+0.242	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070358 vs ICAM3 — CNS

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