Regulation of fat cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of fat cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM3, MCM2, and MCM4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fat cell proliferation activity versus MCM3 in LUAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM3 →	+0.430	+0.046	<.001	<.001	3	6
LUAD	MCM2 →	+0.412	+0.049	<.001	<.001	3	6
LUAD	MCM4 →	+0.463	+0.047	<.001	<.001	3	6
PDAC	MCM7 →	+0.489	+0.053	<.001	<.001	3	6
GBM	DHFR →	+0.557	+0.062	<.001	<.001	3	5
PDAC	MCM5 →	+0.496	+0.053	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070344 vs MCM3 — LUAD

Explore this scatter interactively →