Regulation of fat cell proliferation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of fat cell proliferation pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Regulation of fat cell proliferation pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and READ, show the opposite pattern, with higher activity associated with better survival.

UVM, STAD, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	III,IV	0.870	0.411	.004	58	view →
STAD	OS	Quartile	All	0.408	0.636	.001	45	view →
KICH	OS	Median	II,III,IV	0.507	0.954	.001	38	view →
LIHC	OS	Median	All	0.611	0.785	<.001	37	view →
KIRC	DFS	Quartile	All	0.463	0.674	.001	37	view →
READ	OS	Median	All	0.804	0.452	.009	28	view →
ACC	OS	Tertile	All	0.738	0.968	.002	23	view →
SKCM	OS	Median	III,IV	0.868	0.724	.001	22	view →
KIRP	DFS	Tertile	All	0.871	0.987	.002	21	view →
PRAD	DFS	Median	All	0.898	0.961	<.001	18	view →
UCS	OS	Tertile	III,IV	0.349	0.705	.044	12	view →
CHOL	DFS	Median	IV	0.251	0.794	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0070344–UVM (OS)

Open the UVM breakdown →