Positive regulation of G0 to G1 transition

Across TCGA patient cohorts, RNA activity of the Positive regulation of G0 to G1 transition pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, WNK1, and NCAPD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of G0 to G1 transition activity versus TOP2A in GBM (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TOP2A →	+0.616	+0.064	.001	<.001	3	5
BRCA	WNK1 →	+0.249	+0.076	.002	<.001	3	5
CCRCC	NCAPD2 →	+0.507	+0.093	.005	<.001	3	5
CCRCC	SCLY →	-0.372	-0.051	<.001	.003	3	4
GBM	SMC2 →	+0.478	+0.046	.001	.003	3	4
LSCC	SPAST →	+0.418	+0.080	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070318 vs TOP2A — GBM

Explore this scatter interactively →