Lens fiber cell differentiation

Across TCGA cell cohorts, RNA activity of the Lens fiber cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMPPB, EPHA2, and SMAD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lens fiber cell differentiation activity versus GMPPB in SOFT_TISSUE (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GMPPB →	-1.266	-0.324	.007	<.001	3	4
CNS	EPHA2 →	+1.262	+0.491	<.001	.006	3	3
BLOOD_Leukemia	SMAD1 →	-2.750	-1.023	<.001	.002	3	3
LUNG_NSCLC_LUAD	PSTK →	-0.823	-0.741	.005	.004	3	3
SKIN	KBTBD6 →	-0.703	-1.085	.005	.008	3	3
SKIN	STON1 →	-1.252	-1.263	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070306 vs GMPPB — SOFT_TISSUE

Explore this scatter interactively →