Cellular response to hydrogen peroxide

Across TCGA patient cohorts, RNA activity of the Cellular response to hydrogen peroxide pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP210, HDAC10, and CRY2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to hydrogen peroxide activity versus NUP210 in PDAC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NUP210 →	+0.535	+0.221	<.001	.001	3	4
GBM	HDAC10 →	+0.229	+0.127	.001	.009	3	3
BRCA	CRY2 →	-0.616	-0.247	.001	<.001	3	3
LSCC	STARD13 →	-0.504	-0.117	<.001	<.001	3	3
LUAD	ZNF296 →	+0.213	+0.183	.007	.004	3	3
PDAC	LMNB1 →	+0.433	+0.200	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070301 vs NUP210 — PDAC

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