Actin-mediated cell contraction

Across TCGA patient cohorts, RNA activity of the Actin-mediated cell contraction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF667-AS1, FILIP1, and MMRN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin-mediated cell contraction activity versus ZNF667-AS1 in BRCA (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF667-AS1 →	+0.655	+0.556	.004	.001	3	5
LUAD	FILIP1 →	+0.849	+0.214	.001	.001	3	4
LUAD	MMRN2 →	+0.751	+0.166	<.001	.003	3	4
LUAD	RNU6-242P →	+0.770	+0.159	.005	.007	3	4
LUAD	CHMP1B →	+0.610	+0.205	<.001	.003	3	4
CCRCC	C7 →	+1.632	+0.917	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070252 vs ZNF667-AS1 — BRCA

Explore this scatter interactively →