Protein poly-ADP-ribosylation

Across TCGA patient cohorts, RNA activity of the Protein poly-ADP-ribosylation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YME1L1, HCCS, and PSME1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein poly-ADP-ribosylation activity versus YME1L1 in LUAD (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	YME1L1 →	-0.242	-0.056	.005	.003	3	6
PDAC	HCCS →	-0.333	-0.056	<.001	<.001	3	6
HNSC	PSME1 →	+0.267	+0.070	.003	.001	3	6
BRCA	BYSL →	-0.389	-0.047	<.001	<.001	3	5
LSCC	ANXA6 →	+0.546	+0.093	<.001	<.001	3	5
PDAC	PHF21A →	+0.265	+0.044	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070212 vs YME1L1 — LUAD

Explore this scatter interactively →