Protein poly-ADP-ribosylation

Across TCGA cell cohorts, RNA activity of the Protein poly-ADP-ribosylation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF189, SDE2, and CLSTN1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein poly-ADP-ribosylation activity versus ZNF189 in OESOPHAGUS (Pearson r = 0.97).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF189 →	+0.983	+0.320	.003	.002	3	2
PANCREAS	SDE2 →	+0.953	+0.173	.009	.002	3	2
OESOPHAGUS	CLSTN1 →	+0.846	+0.320	.008	.002	3	2
PANCREAS	FAP →	+0.343	+0.173	<.001	.002	3	2
BLOOD_Leukemia	INTS10 →	+0.342	+0.218	.007	.008	3	1
BLOOD_Leukemia	UBA2 →	-0.360	-0.218	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070212 vs ZNF189 — OESOPHAGUS

Explore this scatter interactively →