Positive regulation of tooth mineralization

Across TCGA patient cohorts, RNA activity of the Positive regulation of tooth mineralization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT18P57, RN7SKP266, and LINC02688, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of tooth mineralization activity versus KRT18P57 in HNSC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KRT18P57 →	-0.527	-0.344	.001	.001	3	3
HNSC	RN7SKP266 →	-0.578	-0.220	<.001	.002	3	3
LUAD	LINC02688 →	+0.934	+0.321	.006	.004	3	3
PDAC	HSD11B1-AS1 →	-0.493	-0.880	.001	<.001	3	3
BRCA	MIR4269 →	+0.634	+0.713	.002	.003	3	3
PDAC	PCNX1 →	-0.326	-0.901	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070172 vs KRT18P57 — HNSC

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