Mitochondrial translational elongation

Across TCGA cell cohorts, RNA activity of the Mitochondrial translational elongation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM219A, KATNAL1, and CALU, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial translational elongation activity versus FAM219A in LUNG_NSCLC_LUSC (Pearson r = -0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FAM219A →	-1.870	-0.186	<.001	.003	3	6
LUNG_NSCLC_LUSC	KATNAL1 →	-2.110	-0.211	.002	.007	3	6
LUNG_NSCLC_LUAD	CALU →	-0.940	-0.157	.001	<.001	2	6
LUNG_SCLC	SENP7 →	-1.128	-0.234	.002	<.001	3	5
BLOOD_Leukemia	LNPK →	-0.832	-0.200	.004	.001	3	5
BLOOD_Leukemia	UTRN →	-1.147	-0.197	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070125 vs FAM219A — LUNG_NSCLC_LUSC

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