Mitochondrial translational elongation

Across TCGA pan-cancer cohorts, RNA activity of the Mitochondrial translational elongation pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Mitochondrial translational elongation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and ACC, show the opposite pattern, with higher activity associated with better survival.

UCEC, READ, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.790	0.881	.001	66	view →
READ	OS	Tertile	II,III,IV	1.000	0.369	.002	36	view →
ACC	DFS	Tertile	III,IV	0.470	0.074	.001	33	view →
STAD	DFS	Median	IV	0.238	0.745	.001	30	view →
THCA	OS	Median	All	0.983	0.993	.009	25	view →
MESO	OS	Median	All	0.298	0.463	.010	22	view →
ESCA	OS	Median	All	0.623	0.773	.007	19	view →
LIHC	OS	Median	III,IV	0.791	0.497	<.001	17	view →
BRCA	OS	Tertile	III,IV	0.955	0.878	.008	14	view →
LGG	DFS	Tertile	All	0.620	0.319	.008	13	view →
UCS	DFS	Quartile	II,III,IV	0.421	0.113	.039	6	view →
UVM	DFS	Quartile	All	0.919	0.655	.047	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0070125–UCEC (DFS)

Open the UCEC breakdown →