Protein-lipid complex assembly

Across TCGA patient cohorts, RNA activity of the Protein-lipid complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3R5, CD28, and GIMAP8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-lipid complex assembly activity versus PIK3R5 in GBM (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIK3R5 →	+0.747	+0.162	<.001	<.001	3	6
GBM	CD28 →	+0.547	+0.123	<.001	<.001	3	6
UCEC	GIMAP8 →	+0.592	+0.207	.009	.003	3	5
UCEC	MSL1 →	-0.492	-0.269	.001	<.001	3	5
GBM	ARID2 →	-0.419	-0.159	<.001	<.001	3	5
LSCC	TADA2A →	-0.484	-0.132	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0065005 vs PIK3R5 — GBM

Explore this scatter interactively →