Protein-DNA complex assembly

Across TCGA patient cohorts, RNA activity of the Protein-DNA complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and RRM2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-DNA complex assembly activity versus SMC2 in LUAD (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMC2 →	+0.646	+0.060	<.001	<.001	3	9
LUAD	SMC4 →	+0.644	+0.060	<.001	<.001	3	9
LUAD	RRM2 →	+0.934	+0.057	<.001	<.001	3	9
LUAD	TOP2A →	+1.153	+0.060	<.001	<.001	3	9
LUAD	TPX2 →	+0.947	+0.058	<.001	<.001	3	9
BRCA	UNG_S23 →	+1.029	+0.026	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0065004 vs SMC2 — LUAD

Explore this scatter interactively →