Regulation of mitochondrial gene expression

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial gene expression pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSNARE1, MZT1, and DDX3X, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial gene expression activity versus TSNARE1 in BLOOD_Leukemia (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSNARE1 →	-1.728	-0.184	.001	<.001	3	5
SKIN	MZT1 →	+0.524	+0.133	.001	<.001	3	5
BLOOD_Leukemia	DDX3X →	+0.668	+0.154	.001	<.001	3	5
BLOOD_Leukemia	SHMT1 →	+1.167	+0.173	<.001	<.001	3	4
SOFT_TISSUE	SF3B3 →	+0.581	+0.146	.006	.001	3	4
SOFT_TISSUE	NEDD4L →	-3.249	-0.168	.009	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062125 vs TSNARE1 — BLOOD_Leukemia

Explore this scatter interactively →