Establishment of protein localization to plasma membrane

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRSS8, MYO5C, and SCNN1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to plasma membrane activity versus PRSS8 in LUAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRSS8 →	+0.767	+0.189	.001	.003	2	6
LUAD	MYO5C →	+0.412	+0.155	.003	.008	3	4
UCEC	SCNN1B →	+1.732	+0.208	.001	.006	2	5
LUAD	LRBA →	+0.373	+0.175	<.001	.002	3	4
LUAD	ARSD →	+0.758	+0.213	<.001	<.001	3	4
BRCA	TTC39A →	+0.882	+0.161	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061951 vs PRSS8 — LUAD

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