Establishment of protein localization to plasma membrane

Across TCGA pan-cancer cohorts, RNA activity of the Establishment of protein localization to plasma membrane pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 62 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Establishment of protein localization to plasma membrane pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and SKCM, show the opposite pattern, with higher activity associated with better survival.

BRCA, SKCM, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Quartile	III,IV	0.931	0.723	<.001	78	view →
SKCM	OS	Quartile	All	0.442	0.260	<.001	52	view →
UCS	OS	Median	II,III,IV	0.630	0.229	.004	50	view →
LUAD	OS	Tertile	All	0.477	0.305	<.001	45	view →
LGG	OS	Median	All	0.351	0.497	<.001	39	view →
KICH	DFS	Tertile	II,III,IV	0.571	0.954	.004	33	view →
ACC	OS	Tertile	III,IV	1.000	0.656	.004	25	view →
PAAD	OS	Quartile	II,III,IV	0.783	0.376	.008	22	view →
GBM	OS	Quartile	All	0.205	0.438	.005	21	view →
UVM	OS	Tertile	III,IV	0.253	1.000	.010	20	view →
KIRC	DFS	Median	III,IV	0.742	0.528	.009	19	view →
BLCA	DFS	Median	All	0.180	0.461	.017	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0061951–BRCA (OS)

Open the BRCA breakdown →