Negative regulation of astrocyte activation

Across TCGA patient cohorts, RNA activity of the Negative regulation of astrocyte activation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNTROB, LSM3, and SYNPO2_T755, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of astrocyte activation activity versus CNTROB in BRCA (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNTROB →	+0.329	+0.210	.002	<.001	3	2
BRCA	LSM3 →	-0.449	-0.315	<.001	<.001	3	2
LUAD	SYNPO2_T755 →	+0.829	+0.135	.002	.001	3	2
LUAD	CALD1_S202 →	+1.770	+0.178	.002	.005	3	2
GBM	CDK7 →	-0.331	-0.885	<.001	<.001	3	2
LUAD	FUS →	-0.412	-0.174	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061889 vs CNTROB — BRCA

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