Cytoskeleton-dependent cytokinesis

Across TCGA patient cohorts, RNA activity of the Cytoskeleton-dependent cytokinesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2, SMC2, and SMC4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoskeleton-dependent cytokinesis activity versus RRM2 in LUAD (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RRM2 →	+0.811	+0.063	<.001	<.001	3	8
BRCA	SMC2 →	+0.588	+0.027	<.001	.002	3	8
BRCA	SMC4 →	+0.635	+0.028	<.001	.002	3	8
LUAD	TOP2A →	+1.056	+0.071	<.001	<.001	3	8
BRCA	KIFC1 →	+0.606	+0.026	<.001	.001	3	8
GBM	MIOS →	-0.178	-0.041	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061640 vs RRM2 — LUAD

Explore this scatter interactively →