Ganglion development

Across TCGA patient cohorts, RNA activity of the Ganglion development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTHRC1, SULF1, and CCDC80, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ganglion development activity versus CTHRC1 in OV (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CTHRC1 →	+0.912	+0.091	.001	<.001	3	8
LSCC	SULF1 →	+0.665	+0.075	<.001	<.001	3	7
OV	CCDC80 →	+0.836	+0.070	.003	.001	3	7
LSCC	COL5A1 →	+0.610	+0.081	<.001	<.001	3	7
OV	FKBP7 →	+0.556	+0.066	<.001	<.001	3	7
OV	GASK1B_S200 →	+0.692	+0.058	.002	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061548 vs CTHRC1 — OV

Explore this scatter interactively →