Ganglion development

Across TCGA cell cohorts, RNA activity of the Ganglion development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDAR, HPRT1, and RNF213, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDAR grouped by Ganglion development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EDAR →	+2.442	+0.986	<.001	.002	3	5
LUNG_NSCLC_LUSC	HPRT1 →	-0.910	-1.630	.009	<.001	3	4
LUNG_SCLC	RNF213 →	+1.117	+1.429	.001	<.001	3	4
LUNG_NSCLC_LUAD	GAREM1 →	+0.615	+0.520	.001	.002	3	4
URINARY_TRACT	RASSF6 →	+2.153	+1.250	<.001	<.001	3	4
LUNG_NSCLC_LUAD	GPX2 →	+3.196	+0.543	.004	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDAR by Ganglion development activity — PANCREAS

Explore this box plot interactively →