Ganglion development

Across TCGA cell cohorts, RNA activity of the Ganglion development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDHAF1, ZNF681, and U2AF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ganglion development activity versus SDHAF1 in BLOOD_Lymphoma (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SDHAF1 →	-0.744	-1.018	<.001	.004	3	4
LUNG_NSCLC_LUSC	ZNF681 →	-1.329	-0.232	.005	.006	3	4
BLOOD_Myeloma	U2AF1 →	+1.579	+1.702	.002	.003	2	4
BLOOD_Myeloma	KLHL26 →	+0.581	+1.552	<.001	<.001	3	3
BLOOD_Myeloma	RTKN2 →	+1.726	+1.552	<.001	<.001	3	3
BLOOD_Myeloma	DGKG →	+2.650	+1.552	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061548 vs SDHAF1 — BLOOD_Lymphoma

Explore this scatter interactively →