Cell adhesion involved in heart morphogenesis

Across TCGA patient cohorts, RNA activity of the Cell adhesion involved in heart morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB2, NNMT, and FSTL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell adhesion involved in heart morphogenesis activity versus TGFB2 in LSCC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TGFB2 →	+1.111	+0.106	<.001	<.001	3	6
GBM	NNMT →	+0.827	+0.053	.004	.006	3	5
BRCA	FSTL1 →	+0.595	+0.067	<.001	<.001	3	5
LUAD	SPATS2L →	+0.438	+0.075	<.001	<.001	3	5
COAD	RIPOR1 →	-0.290	-0.041	<.001	.004	3	4
GBM	AK2 →	+0.321	+0.060	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061343 vs TGFB2 — LSCC

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