Cell adhesion involved in heart morphogenesis

Across TCGA cell cohorts, RNA activity of the Cell adhesion involved in heart morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TACR2, ENO2, and DHX33, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TACR2 grouped by Cell adhesion involved in heart morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TACR2 →	-0.278	-0.221	.003	.002	3	4
KIDNEY	ENO2 →	+0.251	+0.239	.005	<.001	3	4
SOFT_TISSUE	DHX33 →	-0.132	-1.096	.001	<.001	3	4
OESOPHAGUS	RPL10 →	-0.337	-0.196	.001	.003	3	3
BREAST	IRGQ →	-0.299	-1.533	<.001	<.001	3	3
OESOPHAGUS	SLC29A2 →	-0.147	-0.170	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TACR2 by Cell adhesion involved in heart morphogenesis activity — LIVER

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