Canonical Wnt signaling pathway involved in heart development

pathway activity — cross-omics
GO:0061316Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Canonical Wnt signaling pathway involved in heart development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPINDOC_S251, UVSSA_S281, and BMP2K_S949, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVSPINDOC_S251 →+0.876+0.172<.001.00134
HNSCUVSSA_S281 →-0.949-0.307<.001<.00134
PDACBMP2K_S949 →+1.785+0.382<.001<.00134
OVRENBP_S416 →+0.830+0.159<.001.00133
OVSCAMP3_S76 →-0.712-0.110<.001<.00133
OVSEC16A_S1327 →-0.565-0.183<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration