Retina vasculature development in camera-type eye

Across TCGA cell cohorts, RNA activity of the Retina vasculature development in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALNT5, GJA1, and PARS2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina vasculature development in camera-type eye activity versus GALNT5 in CNS (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GALNT5 →	+3.011	+1.818	.006	<.001	3	2
CNS	GJA1 →	+1.186	+1.134	.001	.009	3	2
CNS	PARS2 →	-0.455	-1.510	.002	<.001	3	2
CNS	SEMA4D →	-1.291	-1.446	.004	<.001	3	2
CNS	QSER1 →	-0.623	-1.540	.006	<.001	3	2
CNS	FAP →	+3.216	+1.588	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061298 vs GALNT5 — CNS

Explore this scatter interactively →