Retina vasculature development in camera-type eye

Across TCGA pan-cancer cohorts, RNA activity of the Retina vasculature development in camera-type eye pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Retina vasculature development in camera-type eye pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and HNSC, show the opposite pattern, with higher activity associated with better survival.

LUAD, HNSC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.532	0.272	<.001	56	view →
HNSC	OS	Tertile	III,IV	0.578	0.310	.005	54	view →
KIRP	DFS	Tertile	All	0.525	0.818	.003	41	view →
THCA	DFS	Tertile	II,III,IV	0.895	0.251	.005	37	view →
UVM	OS	Quartile	III,IV	0.234	1.000	.004	37	view →
MESO	OS	Median	All	0.286	0.474	.002	24	view →
KIRC	DFS	Median	III,IV	0.714	0.570	.006	16	view →
ESCA	DFS	Quartile	All	0.463	0.241	.021	15	view →
UCS	DFS	Quartile	II,III,IV	0.610	0.220	.011	14	view →
LIHC	DFS	Quartile	III,IV	0.793	0.302	.016	14	view →
UCEC	DFS	Median	II,III,IV	0.535	0.500	.014	12	view →
SKCM	OS	Tertile	II,III,IV	0.902	0.728	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0061298–LUAD (OS)

Open the LUAD breakdown →