Fungiform papilla development

Across TCGA patient cohorts, RNA activity of the Fungiform papilla development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MED23, ARHGAP9, and ADNP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fungiform papilla development activity versus MED23 in BRCA (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MED23 →	+0.282	+0.078	<.001	<.001	3	6
COAD	ARHGAP9 →	-0.468	-0.072	<.001	.001	3	6
LSCC	ADNP →	+0.485	+0.158	<.001	<.001	3	6
LSCC	ADNP_S608 →	+0.721	+0.152	.001	<.001	3	6
LSCC	FGD2_S654 →	-0.588	-0.104	<.001	<.001	3	6
LSCC	LSP1_S252 →	-0.566	-0.126	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061196 vs MED23 — BRCA

Explore this scatter interactively →