Somite development

Across TCGA patient cohorts, RNA activity of the Somite development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, ADD3, and MYO1G, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somite development activity versus UPP1 in GBM (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UPP1 →	-0.700	-0.043	.006	.001	3	7
BRCA	ADD3 →	+0.507	+0.024	<.001	.003	3	7
LUAD	MYO1G →	-0.504	-0.029	<.001	.001	3	6
COAD	RNF213 →	-0.311	-0.024	.002	.003	3	6
COAD	SEC24A →	-0.275	-0.029	<.001	.001	3	6
PDAC	SFRP1 →	+1.017	+0.038	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061053 vs UPP1 — GBM

Explore this scatter interactively →