Eyelid development in camera-type eye

Across TCGA cell cohorts, RNA activity of the Eyelid development in camera-type eye pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARNTL2, CUL9, and HLA-DRB6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARNTL2 grouped by Eyelid development in camera-type eye-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ARNTL2 →	-0.148	-1.522	.007	.002	3	3
OESOPHAGUS	CUL9 →	+0.227	+1.613	.005	<.001	3	2
OESOPHAGUS	HLA-DRB6 →	-0.343	-1.633	<.001	<.001	3	2
OVARY	SUCLG2 →	-0.383	-1.512	.001	.002	3	2
OVARY	KIR3DL2 →	-0.216	-1.522	.008	.002	3	2
OVARY	GNB5 →	-0.337	-1.973	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARNTL2 by Eyelid development in camera-type eye activity — OVARY

Explore this box plot interactively →