Establishment of endothelial barrier

Across TCGA cell cohorts, RNA activity of the Establishment of endothelial barrier pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMSB15B, SNRNP27, and LTO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMSB15B grouped by Establishment of endothelial barrier-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMSB15B →	+2.265	+1.418	<.001	<.001	3	4
SOFT_TISSUE	SNRNP27 →	+0.738	+1.434	.005	<.001	3	4
SOFT_TISSUE	LTO1 →	-0.527	-1.078	.006	.002	3	4
SOFT_TISSUE	C3orf38 →	+0.677	+1.140	.004	<.001	3	4
SOFT_TISSUE	ZNF665 →	+1.082	+1.099	.009	.001	3	4
LIVER	RNF185 →	+0.694	+1.349	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMSB15B by Establishment of endothelial barrier activity — STOMACH

Explore this box plot interactively →