Cardiac fibroblast cell differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac fibroblast cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS1, TLN1_S2040, and SORBS1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac fibroblast cell differentiation activity versus TNS1 in BRCA (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNS1 →	+0.488	+0.100	<.001	<.001	3	10
BRCA	TLN1_S2040 →	+0.686	+0.097	<.001	<.001	3	10
UCEC	SORBS1 →	+0.714	+0.091	.001	.001	3	9
UCEC	SORBS3 →	+0.490	+0.097	<.001	.001	3	9
CCRCC	SYNPO2 →	+0.817	+0.114	<.001	<.001	3	9
BRCA	TLN2 →	+0.606	+0.103	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060935 vs TNS1 — BRCA

Explore this scatter interactively →