Cardiac fibroblast cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac fibroblast cell differentiation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Cardiac fibroblast cell differentiation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and SCLC, show the opposite pattern, with higher activity associated with better survival.

KIRC, LGG, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.902	0.819	.001	102	view →
LGG	DFS	Median	All	0.672	0.791	<.001	37	view →
SCLC	DFS	Quartile	All	0.843	0.537	.002	36	view →
KIRP	DFS	Median	III,IV	0.422	0.752	.003	31	view →
MESO	OS	Median	All	0.281	0.464	.006	27	view →
THCA	DFS	Quartile	IV	0.409	1.000	.006	20	view →
SKCM	OS	Median	II,III,IV	0.401	0.221	.004	17	view →
OV	DFS	Quartile	II,III,IV	0.330	0.428	.027	16	view →
ESCA	OS	Quartile	III,IV	0.623	0.271	.006	15	view →
DLBC	DFS	Quartile	All	0.072	0.869	.008	14	view →
UVM	OS	Median	III,IV	1.000	0.634	.018	14	view →
COAD	DFS	Median	II,III,IV	0.671	0.796	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0060935–KIRC (DFS)

Open the KIRC breakdown →